At which week of gestation is Rho(D) immune globulin typically administered to an Rh-negative client?

Rho(D) immune globulin is typically administered to Rh-negative clients around the 28th week of gestation. This administration is critical for preventing Rh incompatibility issues that can arise during pregnancy. If an Rh-negative mother carries an Rh-positive fetus, she may develop antibodies against the Rh factor, which can lead to hemolytic disease of the newborn in future pregnancies.

By providing Rho(D) immune globulin at 28 weeks, healthcare providers can prevent the mother's immune system from creating these antibodies, thereby protecting both the current pregnancy and any future pregnancies. It's also important to administer this immunoglobulin within 72 hours after delivery if the newborn is found to be Rh-positive. The timing of the 28-week administration is supported by clinical guidelines to ensure risk mitigation during the critical period of fetal development.