What is a true statement regarding transdermal estradiol?

Transdermal estradiol is designed for slow absorption through the skin, which allows for a steady release of the hormone into the bloodstream. This method of administration helps maintain consistent hormone levels, reducing fluctuations associated with oral forms of estradiol. The slow absorption is beneficial for individuals needing hormone replacement therapy, as it minimizes side effects and improves adherence to the treatment regimen.

The other options do not accurately reflect the properties or recommendations for the use of transdermal estradiol. For instance, estradiol does not reduce estrogen levels; instead, it provides supplemental estrogen. The patches are typically changed weekly rather than monthly, making the adherence to therapy easier. While using sunscreen is important for skin protection, it is not specifically required when using estradiol patches unless directed by a healthcare professional based on individual skin sensitivity or exposure recommendations.