Which medication may cause photophobia as an adverse effect?

Clomiphene is associated with photophobia as an adverse effect due to its mechanism of action as a selective estrogen receptor modulator. It is primarily used in ovulation induction for women experiencing infertility, and one of the notable side effects is its impact on mood and sensory perceptions, including light sensitivity. This can be linked to the changes in estrogen levels and hormonal fluctuations that the medication causes in the body.

The other medications listed do not typically emphasize photophobia as a side effect. Nifedipine is a calcium channel blocker often used for hypertension and angina, while alendronate is a bisphosphonate used for osteoporosis. Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) used primarily for pain and inflammation. Each of these has its own adverse effects, but photophobia is not a common or significant concern with them, highlighting why clomiphene stands out in this context.